2. Signaling Pathways
  3. Metabolic Enzyme/Protease
  4. Drug Metabolite

Drug Metabolite

Drug Metabolite

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Drug metabolite results when a drug is metabolized into a modified form which continues to produce effects. Drug metabolism redox reactions such as heteroatom dealkylations, hydroxylations, heteroatom oxygenations, reductions, and dehydrogenations can yield active metabolites, and in rare cases even conjugation reactions can yield an active metabolite.

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-138166
    Rosuvastatin lactone
    Rosuvastatin lactone is a metabolite of Rosuvastatin (HY-17504A) (HMG-CoA inhibitor).
    Rosuvastatin lactone
  • HY-B1180R
    Vinburnine (Standard)
    Vinburnine (Standard) is the analytical standard of Vinburnine. This product is intended for research and analytical applications. 0
    Vinburnine (Standard)
  • HY-W158239
    4-Methyl-2-[4-(trifluoromethyl)phenyl]-1,3-thiazole-5-carboxylic acid
    4-Methyl-2-[4-(trifluoromethyl)phenyl]-1,3-thiazole-5-carboxylic acid is a metabolite of GW 501516 (HY-10838).
    4-Methyl-2-[4-(trifluoromethyl)phenyl]-1,3-thiazole-5-carboxylic acid
  • HY-135595
    6-Raloxifene-β-D-glucopyranoside
    6-Raloxifene-β-D-glucopyranoside, a derivative of Raloxifene, is a benzothiophene glucuronidated at the 6' postion. 6-Raloxifene-β-D-glucopyranoside is a selective and orally active estrogen receptor antagonist. 6-Raloxifene-β-D-glucopyranoside can be used for inhibiting bone loss and resorption, and lowering lipid levels. 6'-Raloxifene-β-D-glucopyranoside, compound Ia, is extracted from patent US5567820A.
    6-Raloxifene-β-D-glucopyranoside
  • HY-133675
    Mono(5-carboxy-2-ethylpentyl) phthalate
    Mono(5-carboxy-2-ethylpentyl) phthalate (MECPP) is a metabolite of Di-(2-ethylhexyl) phthalate (DEHP). Di(2-ethylhexyl) phthalate is the predominant plasticizer added to rigid polyvinyl chloride (PVC) to impart flexibility, temperature tolerance, optical clarity, strength and resistance to kinking.
    Mono(5-carboxy-2-ethylpentyl) phthalate
  • HY-B1415S
    Clofibric acid-d4
    Clofibric acid-d4 is the deuterium labeled Clofibric acid. Clofibric acid (Chlorofibrinic acid), the pharmaceutically active metabolite of lipid regulators Clofibrate, Etofibrate and Etofyllinclofibrate, is a PPARα agonist which exhibits hypolipidemic effects. Clofibric acid also is an herbicide[1][2][3].
    Clofibric acid-d<sub>4</sub>
  • HY-123349
    5α-Hydroxy-6-keto cholesterol
    5α-Hydroxy-6-keto cholesterol is major metabolite of β-epoxide (5α,6β-epoxycholesterol) during direct exposure of intact cultured human bronchial epithelial cells (16-HBE) to ozone. 5α-Hydroxy-6-keto cholesterol inhibits cholesterol synthesis with an IC50 of 350 nM.
    5α-Hydroxy-6-keto cholesterol
  • HY-136347
    3α-Hydroxy pravastatin sodium
    3α-Hydroxy pravastatin sodium is the major metabolite of Pravastatin. Pravastatin is a competitive HMG-CoA reductase inhibitor.
    3α-Hydroxy pravastatin sodium
  • HY-143907S
    Atorvastatin EP impurity H-d5
    Atorvastatin EP impurity H-d5 is the deuterium labeled Atorvastatin EP impurity H[1].
    Atorvastatin EP impurity H-d<sub>5</sub>
  • HY-137773
    N-Methyl pemetrexed
    N-Methyl pemetrexed is an impurity of Pemetrexed. Pemetrexed is an antifolate cytotoxic agent that can be used for the research of cancer.
    N-Methyl pemetrexed
  • HY-118548
    Tetranor-PGAM
    Tetranor-PGAM is a tetranor-prostaglandin A metabolite. Tetranor-PGAM is a dehydration product of tetranor-PGEM (HY-114988). Tetranor-PGAM can be measured as a surrogate for tetranor-PGEM levels in urine.
    Tetranor-PGAM
  • HY-148051
    Ilaprazole sulfone
    Ilaprazole sulfone is the major metabolite of Ilaprazole (HY-101664), is predominantly catalysed by CYP3A4/5. Ilaprazole (IY-81149) is an orally active proton pump inhibitor.
    Ilaprazole sulfone
  • HY-W008216S
    HMMNI-d3
    HMMNI-d3 is deuterium labeled HMMNI. HMMNI (Hydroxy dimetridazole) is a hydroxy metabolite of Dimetridazole. Dimetridazole is a nitroimidazole class agent that combats protozoan infections[1].
    HMMNI-d<sub>3</sub>
  • HY-143982S
    Mianserin EP impurity E-d4 hydrochloride
    Mianserin EP impurity E-d4 (hydrochloride) is the deuterium labeled Mianserin EP impurity E hydrochloride[1].
    Mianserin EP impurity E-d<sub>4</sub> hydrochloride
  • HY-15550S1
    4'-Hydroxy diclofenac-13C6
    4'-Hydroxy diclofenac-13C6 is the 13C labeled 4'-Hydroxy diclofenac[1]. 4'-Hydroxy diclofenac is an orally active metabolite of Diclofenac (HY-15036) by cytochrome P450 2C9 (CYP2C9). 4'-Hydroxy diclofenac has anti-inflammatory and analgesic properties[2][3].
    4'-Hydroxy diclofenac-<sup>13</sup>C<sub>6</sub>
  • HY-12753S1
    Debutyldronedarone-d6 hydrochloride
    Debutyldronedarone-d6 (hydrochloride) is deuterium labeled Debutyldronedarone. Debutyldronedarone is a major circulating active metabolite of dronedarone (HY-A0016) in humans. Debutyldronedarone exhibits a potency that is 1/10 to 1/3 of that of the parent agent[1][2].
    Debutyldronedarone-d<sub>6</sub> hydrochloride
  • HY-13318A
    Oseltamivir acid hydrochloride
    Oseltamivir acid hydrochloride is an active metabolite of the antiviral agent Oseltamivir (HY-13317) ethylester. Oseltamivir acid hydrochloride belongs to baseline toxicants in toxicity ratio analysis.
    Oseltamivir acid hydrochloride
  • HY-135385
    Dihydro Dutasteride
    Dihydro Dutasteride is a metabolite of Dutasteride. Dutasteride is a potent inhibitor of both 5 alpha-reductase isozymes.
    Dihydro Dutasteride
  • HY-124414S
    4'-Hydroxytamoxifen-d6 (contains up to 10% E isomer)
    4'-Hydroxytamoxifen-d6 (contains up to 10% E isomer) is deuterium labeled 4'-Hydroxy Tamoxifen. 4'-Hydroxytamoxifen is a metabolite of Tamoxifen.
    4'-Hydroxytamoxifen-d<sub>6</sub> (contains up to 10% E isomer)
  • HY-131282
    Ivabradine impurity 2
    Ivabradine impurity 2 is an Ivabradine impurity. Ivabradine is an orally bioavailable, hyperpolarization-activated, cyclic nucleotide-gated (HCN) channel blocker.
    Ivabradine impurity 2
Cat. No. Product Name / Synonyms Application Reactivity